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Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes

Authors :
Kevin John Merchant
Christopher John Swain
Sharon Sadowski
Catherine D. Strader
Margaret A. Cascieri
Eileen Mary Seward
Raymond Baker
Verity Margaret Sabin
Simon Neil Owen
Source :
Bioorganic & Medicinal Chemistry Letters. 3:1361-1366
Publication Year :
1993
Publisher :
Elsevier BV, 1993.

Abstract

A series of 3-benzyloxy-derivatives of CP-96,345 has been evaluated and found to have significant affinity for the human NK1 receptor. 3,5-Disubstitution of the benzyl ether has been identified to be essential for high affinity.

Subjects

Subjects :
chemistry.chemical_compound
chemistry
Benzyl ether
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Receptor
Molecular Biology
Biochemistry
Quinuclidine

Details

ISSN :
0960894X
Volume :
3
Database :
OpenAIRE
Journal :
Bioorganic & Medicinal Chemistry Letters
Accession number :
edsair.doi...........08f778f2c2103cd28a1778e558e3fa2d

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