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Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1)
- Source :
- Bioorganic & Medicinal Chemistry Letters. 23:3662-3666
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with advanced solid malignancies.
Details
- ISSN :
- 0960894X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........095c494559927c4501b2a27cf758bee3
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.02.083