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Nitric Acid Promoted Metal-Free Bromothiolation of Internal Alkynes with Hydrobromic Acid and Disulfides
- Source :
- Synlett. 33:1539-1545
- Publication Year :
- 2022
- Publisher :
- Georg Thieme Verlag KG, 2022.
-
Abstract
- A novel, metal-free bromo-thiolation of internal alkynes with hydrobromic acid and disulfides has been developed. The reaction is promoted by commercial-grade nitric acid and is used to construct a series of unexplored β-bromoalkenyl sulfides in moderate to good yield. Most products were obtained with high stereoselectivity as syn-configured tetrasubstituted alkenes. Both sulfide groups of the disulfide reagent were used in this method.
- Subjects :
- Organic Chemistry
Subjects
Details
- ISSN :
- 14372096 and 09365214
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Synlett
- Accession number :
- edsair.doi...........09a34609d191228cb472d2cae4b82b42