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Adjuvante Polychemotherapie zusätzlich zur radikalen operativen Behandlung regionaler Lymphknotenmetastasen beim malignen Melanom

Authors :
H. Bünte
V. Aragon
E. Macher
V. Krieg
Eva-B. Bröcker
Beate M. Czarnetzki
Source :
DMW - Deutsche Medizinische Wochenschrift. 111:732-736
Publication Year :
2008
Publisher :
Georg Thieme Verlag KG, 2008.

Abstract

Thirty-three patients with malignant melanoma and regional lymph node metastases who underwent lymph node dissection were additionally given polychemotherapy with carmustine, hydroxycarbamide and dacarbazine immediately before surgery and up to five times postoperatively. Twenty-nine patients were only treated surgically. These two groups were comparable as regards prognostic criteria, in particular tumour size, ulceration and the number of lymph nodes affected, although the individual follow-up periods varied considerably. The group given chemotherapy showed better results than the control group undergoing surgery alone. The log rank test yielded a significant difference (P less than 0.05) with respect to the probability of relapse-free survival but not as regards probability of survival time. Patients with ulcerated primary melanomas and with a large number of affected lymph nodes had a less favourable prognosis. The major side effects of chemotherapy were transient nausea and bone marrow depression.

Details

ISSN :
14394413 and 00120472
Volume :
111
Database :
OpenAIRE
Journal :
DMW - Deutsche Medizinische Wochenschrift
Accession number :
edsair.doi...........0a5d0f7239ebd9b73a9e54c3cd61dd8a
Full Text :
https://doi.org/10.1055/s-2008-1068522