Back to Search Start Over

Enhanced expression of hemoglobin scavenger receptor and heme oxygenase-1 is associated with aortic valve stenosis in patients undergoing hemodialysis

Authors :
Minoru Yoshiyama
Yasuyuki Kato
Toshihiko Shibata
Kenichi Sugioka
Kei Yunoki
Mayumi Inaba
Makiko Ueda
Takeshi Inoue
Masahiko Ohsawa
Takahiko Naruko
Source :
Hemodialysis International. 18:632-640
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

A high prevalence and a rapid progression of aortic valve stenosis (AS) in patients undergoing hemodialysis (HD) has been reported. In these circumstances, intraleaflet hemorrhage of aortic valve may be related to the development of AS in HD patients. We immunohistochemically examined the relationship among intraleaflet hemorrhage, neovascularization, hemoglobin scavenger receptor (CD163), and heme oxygenase-1 (HO-1) using surgically resected aortic valve specimens from AS patients undergoing HD. The study population consisted of 26 HD patients and 25 non-HD patients with severe AS who had undergone aortic valve replacement. Frozen aortic valve samples surgically obtained from AS patients were stained immunohistochemically with antibodies against smooth muscle cells, macrophages, glycophorin-A (a protein specific to erythrocyte membranes), CD31, CD163, and HO-1. Morphometric analysis demonstrated that the CD163-positive macrophage score, the number of CD31-positive microvessels, and the percentage of glycophorin-A and HO-1-positive area were significantly higher in HD patients than in non-HD patients (CD163-positive macrophage score, P

Details

ISSN :
14927535
Volume :
18
Database :
OpenAIRE
Journal :
Hemodialysis International
Accession number :
edsair.doi...........0a7296d62360503ad8d4a2aeaf90fa11
Full Text :
https://doi.org/10.1111/hdi.12147