Associations of GSTM1 (del) and GSTP1 (Ile105Val) genetic polymorphisms and smoking in a family with congenital malformations

Authors :: Elena N. Voronina
L. A. Gordeeva
I. V. Shatalina
Yu. V. Gareeva
Maksim L. Filipenko
I. M. Sutulina
Source :: Russian Journal of Genetics: Applied Research. 6:197-201
Publication Year :: 2016
Publisher :: Pleiades Publishing Ltd, 2016.
Abstract: The associations of polymorphisms of the GSTM1 (del) and GSTP1 (Ile105Val) genes and smoking in a family with congenital malformations (CMs) in a newborn baby have been studied. The GSTM1 (del) and GSTP1 (Ile105Val) gene polymorphisms themselves are not associated with the risk of CMs in a newborn. However, smoking in a family may increase the risk significance of the GSTP1 (Ile105Val) genotypes in the formation of CMs in a child.

Subjects :: 0301 basic medicine
Genetics
integumentary system
Congenital malformations
030105 genetics & heredity
Biology
urologic and male genital diseases
Human genetics
03 medical and health sciences
GSTP1
health services administration
Genotype
Animal Science and Zoology
neoplasms
Agronomy and Crop Science
Gene
health care economics and organizations

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