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18F-FDG PET/CT predicts microvascular invasion and early recurrence after liver resection for hepatocellular carcinoma
- Source :
- HPB. 21:739-747
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background This study assessed the prognostic value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in the prediction of MVI and early recurrence following resection. Method This prospective study (ClinicalTrials.gov ID: NCT02145013) included 78 consecutive HCC patients who underwent 18F-FDG PET/CT before curative-intent resection from 2014 to 2017. Prognostic factors available before surgery for predicting MVI and early recurrence (≤2 years) were identified by univariate and multivariate analyses. Results The 18F-FDG PET/CT result was positive in 30 (38%) patients. MVI was present in 33% (26/78) of specimens. Early recurrence occurred in 19% (14/74) of surviving patients. PET/CT positivity was the sole independent predictor of MVI (odds ratio [OR] = 3.6, 95% confidence interval [CI] = 1.1–11.2; p = 0.03), with a specificity and sensitivity for predicting MVI of 73% and 62%, respectively. Analysis of variables available before surgery showed that PET/CT positivity (hazard ratio [HR] = 5.8, 95% CI = 1.6–20.4; p = 0.006) and the male sex (HR = 6.6; 95% CI = 1.8–24.2; p = 0.005) were independent predictors of early recurrence. Conclusion 18F-FDG PET/CT predicts MVI and early recurrence after surgery for HCC and could be used to select patients for neoadjuvant treatment.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Hepatology
medicine.diagnostic_test
business.industry
Hazard ratio
Gastroenterology
Odds ratio
medicine.disease
Confidence interval
03 medical and health sciences
0302 clinical medicine
Positron emission tomography
030220 oncology & carcinogenesis
Hepatocellular carcinoma
medicine
Carcinoma
030211 gastroenterology & hepatology
Radiology
Prospective cohort study
business
Subjects
Details
- ISSN :
- 1365182X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- HPB
- Accession number :
- edsair.doi...........0ab01ba85c6b153203c7a65f2b55fb75