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Postnatal neurogenesis in the neuroproliferative areas of the brain

Authors :
V. M. Shevchenko
V. O. Tykholaz
T. V. Khodak
Source :
Reports of Vinnytsia National Medical University. 26:676-680
Publication Year :
2022
Publisher :
Vinnytsia National Pyrogov Memorial Medical University, 2022.

Abstract

Annotation. The purpose of the work is to systematize and analyze existing problematic aspects in the study of postnatal neurogenesis in neuroproliferative areas of the brain. The relevance of this problem is due to the growing share of neurodegenerative diseases and the search for the possibility of their treatment. From the databases PubMed, ScienceDirect, UpToDate, Web of science, Scopus, 28 sources on this problem were selected for consideration, regardless of age, with a predominance of publications from the last 10 years. The state of research related to the study of postnatal neurogenesis in the neuroproliferative areas of the brain (hippocampus) is highlighted as a result of the scientific and theoretical analysis of literature sources. Further branches of research are outlined. The lack of clear data on the structure of different areas of the hippocampus under the action of neurogenesis-inhibiting factors with subsequent stimulation in these same areas was revealed. The need for standardization of immunohistochemical methods of research and improvement of the method of detection of known neurospecific proteins, which are markers of proliferation or apoptosis, has been identified, which will enable both the comparison of the results obtained by different researchers and their interpretation.

Subjects

Subjects :
General Medicine

Details

ISSN :
25229354 and 18177883
Volume :
26
Database :
OpenAIRE
Journal :
Reports of Vinnytsia National Medical University
Accession number :
edsair.doi...........0afb39bdd8e615ee64bf8fa4ac24824f
Full Text :
https://doi.org/10.31393/reports-vnmedical-2022-26(4)-27