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Phenylalanine intraperitoneal injection effect on high-voltage calcium channels in rat hippocampal neurons
- Source :
- Neurophysiology. 23:84-88
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- Neurons from the hippocampus of one-day-old (controls) rats intraperitoneally injected with phenylalanine were isolated and cultured [3, 8]. The potential-dependent calcium input channel (ICa) in hippocampal neurons of controls after five-seven days of culture was made up of two components, low and high voltage, when the membrane potential was fixed under intracellular perfusion. The high-voltage channel was 69±13% of the total calcium channel at Vt = −10 mV. After rats were injected with phenylalanine, the high-voltage ICa significantly decreased to 32±14% of the total channel in the neurons at the same Vt. The low-voltage ICa did not change significantly.
- Subjects :
- Membrane potential
medicine.medical_specialty
Voltage-dependent calcium channel
Physiology
Chemistry
General Neuroscience
medicine.medical_treatment
Intraperitoneal injection
chemistry.chemical_element
Phenylalanine
Hippocampal formation
Calcium
Endocrinology
Biochemistry
Internal medicine
medicine
Hippocampus (mythology)
Perfusion
Subjects
Details
- ISSN :
- 15739007 and 00902977
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Neurophysiology
- Accession number :
- edsair.doi...........0b4bf30939182b5cbc32a7e07ecb49e2
- Full Text :
- https://doi.org/10.1007/bf01052294