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Phenylalanine intraperitoneal injection effect on high-voltage calcium channels in rat hippocampal neurons

Authors :
Galina Skibo
S.V. Savina
Anatoly E. Martynyuk
Source :
Neurophysiology. 23:84-88
Publication Year :
1991
Publisher :
Springer Science and Business Media LLC, 1991.

Abstract

Neurons from the hippocampus of one-day-old (controls) rats intraperitoneally injected with phenylalanine were isolated and cultured [3, 8]. The potential-dependent calcium input channel (ICa) in hippocampal neurons of controls after five-seven days of culture was made up of two components, low and high voltage, when the membrane potential was fixed under intracellular perfusion. The high-voltage channel was 69±13% of the total calcium channel at Vt = −10 mV. After rats were injected with phenylalanine, the high-voltage ICa significantly decreased to 32±14% of the total channel in the neurons at the same Vt. The low-voltage ICa did not change significantly.

Details

ISSN :
15739007 and 00902977
Volume :
23
Database :
OpenAIRE
Journal :
Neurophysiology
Accession number :
edsair.doi...........0b4bf30939182b5cbc32a7e07ecb49e2
Full Text :
https://doi.org/10.1007/bf01052294