Treating neuroendocrine neoplasms in the setting of HIV infection

BACKGROUND: There is a paucity of knowledge regarding neuroendocrine neoplasms (NEN) in patients with HIV infection. OBJECTIVE: To explore the incidence, characteristics and treatment outcomes of NEN in HIV-positive individuals. METHODS: This is a single-center, descriptive cohort study. Patients with HIV and biopsy-confirmed NEN were identified from our data registry. Data were collected retrospectively from medical records. Progression-free and overall survival (OS) were estimated using the Kaplan-Meier method. RESULTS: Nineteen HIV-positive patients with neuroendocrine tumors (NET) (n = 14), neuroendocrine carcinomas (NEC) (n = 2) or Merkel cell carcinoma (MCC) (n = 3) were included (median age at NEN diagnosis, 53 years). In 15 (79%) patients, HIV diagnosis preceded NEN diagnosis by a median of 11 years and 14 were receiving antiretroviral therapy (ART). Of those with data available, 75% had a viral load