Inhibitory Activity Towards Angiotensin Converting Enzyme I of Alchemilla vulgaris

The study was aimed to evaluate the inhibitory activity towards angiotensin converting enzyme I (ACE-I), antioxidant capacity and phenolics of Alchemilla vulgaris (lady’s mantle) naturally grows in Turkey. Aqueous extracts of lady’s mantle were used for enzyme inhibition assay on angiotensin converting enzyme I purified from sheep lungs. Trolox equivalent antioxidant capacity (TEAC) and DPPH assays were also used for monitoring of antioxidant profile of methanolic and aqueous extracts. Total phenolics of the extracts from lady’s mantle were also analyzed. Our research results indicated that lady’s mantle could have important anti-hypertensive effects due to their potent inhibitory activity towards angiotensin converting enzyme I.