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A water soluble hydrazone probe for subsequent fluorescent detection of Zn2+ and S2− in neat aqueous solution and imaging in mitochondria of living cells
- Source :
- Journal of Molecular Structure. 1249:131629
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- A simple water soluble hydrazone sensor (1·Cl) has been developed to selectively chelate with Zn2+ via an O2N donor set, leading to specific fluorescence enhancements. The highly emissive 1-Zn2+ complex can serve as a reversible on-off sensor for S2−. The detection limits of 1·Cl for Zn2+ and S2− are 66.0 and 32.6 nM, respectively. The recognition mechanism was carefully investigated through FL, UV-vis, 1H NMR, ESI-MS, time-resolved fluorescence, and density functional theory (DFT) calculations. Owing to the mitochondria-targeting ability of the terminal quaternary ammonium moiety, 1·Cl was successfully applied to image mitochondrial Zn2+ and S2−.
Details
- ISSN :
- 00222860
- Volume :
- 1249
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Structure
- Accession number :
- edsair.doi...........0d2da4ac3101727985e685143e29c50e