Antibiotic resistance of intestinal strains of Kl. pneumoniae in newborns in a maternity hospital

Antibiotic resistance and resistome of intestinal strains of Kl. pneumoniae colonizing healthy babies in maternity hospitals were studied. According to the results of phenotype studies, Kl. pneumoniae in 92,3% of cases were ESBL producers and showed resistance to ampicillin, amoxiclav, co-trimoxazole, less to ciprofloxacin and nitrofurantoin. 90% of intestinal Kl. pneumoniae had multiple resistance to antimicrobial drugs. According to a genome-wide study, beta-lactamase genes were found in all strains. blaOXA-1 was found in 60%, blaTEM-30 in 70%, blaCTX-M-15 in 70%, blaSHV in 100% of the strains. Genes for resistance to aminoglycosides were found in 90%, fluoroquinolones — in 40%, sulfonamides — in 80%, chloramphenicol — in 70%, tetracycline — in 50%, and trimethoprim – in 70% of Kl. pneumoniae strains.