ChemInform Abstract: A Novel Synthesis of Diverse 2-Amino-5-hydroxy-4H-chromene Derivatives with a Spirooxindole Nucleus by Ca(OH)2-Mediated Three-Component Reactions of Substituted Resorcinols with Isatins and Malononitrile

An efficient and facile one-pot synthesis is described for the preparation of novel 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus using Ca(OH)2-mediated three-component reactions of substituted resorcinols with isatins and malononitrile. This simple method provided a variety of biologically interesting diverse 2-amino-5-hydroxy-4H-chromene derivatives in moderate yields under mild reaction conditions.