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Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells
- Source :
- Medicinal Chemistry Research. 24:3813-3820
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Bisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.
- Subjects :
- Active ingredient
SH-SY5Y
Voltage-dependent calcium channel
Calcium channel
Organic Chemistry
Neurotoxicity
chemistry.chemical_element
Calcium
Pharmacology
medicine.disease
Neuroprotection
chemistry.chemical_compound
chemistry
medicine
General Pharmacology, Toxicology and Pharmaceutics
Hydrogen peroxide
Subjects
Details
- ISSN :
- 15548120 and 10542523
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry Research
- Accession number :
- edsair.doi...........0e015cdb69dc1db640ca1d5549c37b17