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Chloroquine phosphate suppositories in the treatment of childhood malaria in Calabar, Nigeria
- Source :
- Current Therapeutic Research. 56:928-935
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- In a randomized, prospective study of the therapy of acute falciparum malaria in 69 children, aged 6 to 60 months, the results of treatment with chloroquine phosphate suppositories (30 patients) and chloroquine sulfate syrup (39 patients) were compared. Each patient received 25mg chloroquine base/kg body weight over 3 consecutive days (day 0,lO mgkg; day 1,lO mg/kg; and day 2, 5 mg/kg). The parasitologic cure rate was 33% (lo/301 in the chloroquine phosphate suppository group and 36% (14/39) in the chloroquine sulfate syrup group. In addition, the mean pretreatment parasite counts of the chloroquinesensitive cases were not significantly different in the two groups. However, pyrexia resolved slightly more slowly in the suppository group, although all sensitive patients in both groups were afebrile on day 3. The results suggest that chloroquine phosphate suppositories are as effective as chloroquine sulfate syrup in the treatment of children with malaria caused by chloroquine-sensitive Plasmodium fakiparum.
- Subjects :
- Pharmacology
medicine.medical_specialty
Chemotherapy
Traditional medicine
biology
business.industry
medicine.medical_treatment
Plasmodium falciparum
Suppository
biology.organism_classification
medicine.disease
Gastroenterology
Chloroquine Phosphate
Dosage form
Chloroquine Sulfate
Chloroquine
Internal medicine
medicine
Pharmacology (medical)
business
Malaria
medicine.drug
Subjects
Details
- ISSN :
- 0011393X
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Current Therapeutic Research
- Accession number :
- edsair.doi...........0e84ea22848ce50adce1520b408a3ae2