Interleukin-28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection

Authors :: William Sievert
Martin Weltman
Stuart K. Roberts
Geoffrey W. McCaughan
Matthew T Kitson
Wendy Cheng
Peter Button
Reynold Leung
Jacob George
Gregory J. Dore
Darrell H. G. Crawford
Source :: Journal of Gastroenterology and Hepatology. 29:1458-1462
Publication Year :: 2014
Publisher :: Wiley, 2014.
Abstract: Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naive patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms.

Subjects :: Hepatology
business.industry
Gastroenterology
Single-nucleotide polymorphism
Hepatitis C
medicine.disease
Virus
Interleukin 28B
Fibrosis
Cohort
Genotype
Immunology
medicine
Allele
business

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