Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Authors :: Mohd Azlan Nafiah
Khalijah Awang
Kartini Ahmad
Abdul Manaf Ali
Siow-Ping Tan
Source :: Tetrahedron. 71:3946-3953
Publication Year :: 2015
Publisher :: Elsevier BV, 2015.
Abstract: Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2–4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50

Subjects :: Murraya
biology
Stereochemistry
Carbazole
Organic Chemistry
biology.organism_classification
Biochemistry
HeLa
chemistry.chemical_compound
Rutaceae
chemistry
visual_art
Drug Discovery
visual_art.visual_art_medium
Cytotoxic T cell
Bark

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