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Oncological outcomes of high risk prostate cancer patients between robot-assisted laparoscopic radical prostatectomy and laparoscopic radical prostatectomy in Taiwan
- Source :
- Urological Science.
- Publication Year :
- 2017
- Publisher :
- Medknow, 2017.
-
Abstract
- Objective To compare pathological and oncological outcomes between robotic-assisted laparoscopic radical prostatectomy (RaLRP) and laparoscopic radical prostatectomy (LRP) among high-risk prostate cancer patient in a tertiary center in Taiwan. Materials and methods From November 2003 to October 2013, 129 high-risk prostate cancer patients receiving minimally-invasive radical prostatectomy were included. The Kaplan–Meier analysis was used for measuring biochemical recurrence-free survival (BFS). Multivariate logistic regression models and Cox proportional hazards regression models were used to determine predictors of positive surgical margin and BFS. Results Among the 129 high-risk prostate cancer patients included, 80 (62%) patients received LRP and 49 (38%) patients received RaLRP. There was no significant difference of positive surgical margin and biochemical recurrence rate between RaLRP and LRP group (P = 0.802 and 0.292). Higher pathological T stage predicted an increased likelihood of positive margins (OR = 3.44, 95% CI [1.45, 8.18], P = 0.005). Higher initial PSA level (HR = 2.88, 95% CI [1.04, 7.94], P = 0.041) and positive surgical margin (HR = 2.55, 95% CI [1.20, 5.44], P = 0.015) were poor prognostic factors for BFS. Conclusion RaLRP can be considered among high-risk prostate cancer in Asian people with comparable oncological outcomes to LRP. Higher pathological T stage was associated with increased likelihood of positive margins, patients with higher iPSA level and positive surgical margin had worsen biochemical recurrence-free survival.
- Subjects :
- Oncology
Biochemical recurrence
medicine.medical_specialty
medicine.diagnostic_test
Laparoscopic radical prostatectomy
business.industry
Prostatectomy
Urology
medicine.medical_treatment
030232 urology & nephrology
medicine.disease
Logistic regression
03 medical and health sciences
Prostate cancer
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
medicine
T-stage
Positive Surgical Margin
business
Laparoscopy
Subjects
Details
- ISSN :
- 18795226
- Database :
- OpenAIRE
- Journal :
- Urological Science
- Accession number :
- edsair.doi...........10e4a5a2f3623775fc8067f9cdfcc56c