Verticillane-Type Diterpenoids and an Eudesmanolide-Type Sesquiterpene from the Formosan Soft CoralCespitularia hypotentaculata

Four new diterpenes, cespihypotins W–Z (1–4), having the verticillane skeleton and characterized by an α,β-unsaturated γ-hydroxycyclopentanone moiety, and a new eudesmanolide-type sesquiterpene, cespilactam A (5), containing an α,β-unsaturated γ-lactam residue, were isolated from the AcOEt-soluble fraction of the Taiwanese soft coral Cespitularia hypotentaculata. The structure and relative configuration of these metabolites was elucidated through extensive interpretation of MS, COSY, HSQC, HMBC, and NOESY experiments and by comparison of their NMR data with those of related compounds.