ChemInform Abstract: Pd-Catalyzed C(sp3)-H Carbonylation of Alkylamines: A Powerful Route to γ-Lactams and γ-Amino Acids

A novel Pd-catalyzed direct C(sp3)–H carbonylation of alkylamines for the synthesis of γ-lactams and γ-amino acids has been developed, in which TEMPO was used as the crucial sole oxidant. The synthetic prospect was demonstrated by the concise total synthesis of rac-Pregbalin.