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From 3D cell culture to organs-on-chips

From 3D cell culture to organs-on-chips

Authors :
Geraldine A. Hamilton
Donald E. Ingber
Dongeun Huh
Source :
Trends in Cell Biology. 21:745-754
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

3D cell-culture models have recently garnered great attention because they often promote levels of cell differentiation and tissue organization not possible in conventional 2D culture systems. We review new advances in 3D culture that leverage microfabrication technologies from the microchip industry and microfluidics approaches to create cell-culture microenvironments that both support tissue differentiation and recapitulate the tissue–tissue interfaces, spatiotemporal chemical gradients, and mechanical microenvironments of living organs. These ‘organs-on-chips' permit the study of human physiology in an organ-specific context, enable development of novel in vitro disease models, and could potentially serve as replacements for animals used in drug development and toxin testing.

Details

ISSN :
09628924
Volume :
21
Database :
OpenAIRE
Journal :
Trends in Cell Biology
Accession number :
edsair.doi...........12456a04d590ab9c0fa1c4a4993c394a
Full Text :
https://doi.org/10.1016/j.tcb.2011.09.005