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Lactose-conjugated porphyrin: synthesis and photobiological evaluation as potential agents for photodynamic therapy

Authors :
Yue Cao
Xiaodong Yang
Bo Ren
Xin Zhang
Source :
Canadian Journal of Chemistry. 99:983-990
Publication Year :
2021
Publisher :
Canadian Science Publishing, 2021.

Abstract

Porphyrin-based photosensitizers are conventional photodynamic agents that are used clinically. However, their clinical applications have been overshadowed by poor water solubility. In addition, they have weak tumor selectivity, which may cause undesirable side effects. The preparation of novel porphyrin derivatives has been explored for potential applications in photodynamic therapy (PDT). To achieve this goal, lactose-conjugated porphyrin nanoparticles (Lac-Por NPs) have been synthesized and characterized. PDT with Lac-Por NPs exhibited tumor-specific cytotoxicity in lactose receptor-overexpressing HepG2 cells in vitro and in vivo. In summary, we designed and synthesized lactose conjugate porphyrins with enhanced water solubility and tumor selectivity. This work expands the application range of porphyrin-based photosensitizers for cancer treatment.

Details

ISSN :
14803291 and 00084042
Volume :
99
Database :
OpenAIRE
Journal :
Canadian Journal of Chemistry
Accession number :
edsair.doi...........1275e5ce9fc99505d8015175b1bd4bb1