ChemInform Abstract: Auto-Tandem Catalysis: Synthesis of Substituted 11H-Indolo[3,2-c]quinolines via Palladium-Catalyzed Intermolecular C-N and Intramolecular C-C Bond Formation

D-Ring substituted 11H-indolo[3,2-c]quinolines (4) have been prepared via auto-tandem consecutive intermolecular Buchwald-Hartwig reaction and intramolecular palladium-catalyzed arylation on 4-chloroquinoline (1) with N-unsubstituted 2-chloroanilines (2). The reported 11H-indolo[3,2-c]quinolines (4) represent the first examples in which tandem catalysis has been used to construct N-unsubstituted carbolines.