ChemInform Abstract: Nickel-Catalyzed Enantioselective Alkylative Coupling of Alkynes and Aldehydes: Synthesis of Chiral Allylic Alcohols with Tetrasubstituted Olefins

Authors :: Qi-Lin Zhou
Shou-Fei Zhu
Yun Yang
Chang-Yue Zhou
Source :: ChemInform. 40
Publication Year :: 2009
Publisher :: Wiley, 2009.
Abstract: A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities.

Subjects :: chemistry.chemical_compound
Allylic rearrangement
Olefin fiber
Phosphoramidite
Nickel
chemistry
Dimethylzinc
Enantioselective synthesis
chemistry.chemical_element
General Medicine
Combinatorial chemistry
Catalysis

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