A novel diastereoselective synthesis of chiral, non-racemic unsymmetrical thioacetals using silicon-induced Pummerer-type reaction

Chiral, non-racemic sulfoxides were reacted with thiols and BSA in the presence of a catalytic amount of TMSOTf in MeCN at rt overnight to give the corresponding chiral, non-racemic anti-thioacetals with high diastereoselectivity.