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MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability
- Source :
- 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII).
- Publication Year :
- 2019
- Publisher :
- IEEE, 2019.
-
Abstract
- This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.
- Subjects :
- Microelectromechanical systems
endocrine system
0303 health sciences
geography
Materials science
geography.geographical_feature_category
Silicon
Pancreatic islets
chemistry.chemical_element
030230 surgery
Islet
Transplantation
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
chemistry
medicine
030304 developmental biology
Biomedical engineering
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
- Accession number :
- edsair.doi...........131939035f2c439dcc34d9aa4ca49c6e