The fibroblast growth factor and intracardiac hemodynamics in mitral valve prolapse in combination with type 1 diabetes mellitus

Objective — to perform the comparative analysis of fibroblast growth factor (FGF)- 2 levels and basic echocardiographic parameters (ECP) in patients with mitral valve prolapse MVP, type 1 diabetes mellitus (DM1) and their combination, depending on the presence of signs of structural and functional changes in the heart valve apparatus and remodeling of the left ventricular (LV) myocardium.Materials and methods. The examinations involved 86 people aged 18 to 33 years (54 (56.8 %) women and 41 (43.2 %) men), including 24 people with MVP without concomitant pathology; 29 patients with MVP and DM1; 33 patients with DM1 without MVP. The control group included 22 practically healthy people matched by age and gender. The establishment of the diagnosis of MVP implemented by echocardiographic criteria L. Freed et al. (2002). Evaluation of the concentration of FGF2 implemented in blood plasma by the enzyme immunoassay (Quantikine reagent kit (Human FGF basic Immunoassay).Results. In patients with MVP and DM1, the higher values of the index of the relative LV wall thickness have been reveled in comparison with the groups of patients with monomorbid MVP and DM1. The presence of MVP, both monomorbid and in combination with type 1 diabetes, was accompanied by an increase in the FGF 2 levels compared to the control: with isolated MVP, it was higher, respectively, by 25 %, with comorbid pathology it was more than 1.5 times higher than the control values.Conclusions. The most significant differences in the indices of intracardiac hemodynamics and FGF 2 compared with control were observed in patients with combination of MVP and type 1 diabetes, which may indicate the influence of diabetic metabolic processes on further structural changes in the mitral valve CT, LV myocardium, the marker of which is FGF 2. Less difference in the FGF-2 levels was revealed between the patients with isolated mitral valve prolapse and control group.