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Bendamustine, lenalidomide and dexamethasone (BRd) has high activity as 2nd-line therapy for relapsed and refractory multiple myeloma - a phase II trial
- Source :
- British Journal of Haematology. 176:770-782
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Summary The combination of lenalidomide (Revlimid®, R) and dexamethasone (d) is a standard regimen for patients with relapsed/refractory multiple myeloma (rrMM). With this regimen, only a small fraction of patients will achieve high quality responses [≥ very good partial response (VGPR)]. The combination of bendamustine (B), lenalidomide and dexamethasone (BRd) has shown high efficacy in patients with advanced rrMM. However, dose-limiting haematotoxicity restricted its use in extensively pre-treated patient populations. This prospective, multicentre Phase II study evaluated the efficacy and safety of BRd in rrMM patients with one prior line of therapy. Fifty patients were enrolled (median age 68·5 years [range 46–83]) and were treated with B 75 mg/m2 days 1, 2; R 25 mg days 1–21 and d (40/20 mg) days 1, 8, 15 and 22, for 6 28-day induction cycles, followed by 12 cycles with Rd alone. Pegfilgrastim was administered according to protocol-defined criteria. The study aimed to demonstrate a complete response (CR)/VGPR rate of >40% after induction therapy. Of 45 evaluable patients, 23 (51%) achieved a CR/VGPR. Grade 4 neutropenia or thrombocytopenia occurred in 17 (34%) and 8 (16%) of patients, respectively. BRd is a safe and efficacious regimen as a second line treatment for rrMM, leading to high quality responses in a considerable proportion of patients.
- Subjects :
- Oncology
Bendamustine
medicine.medical_specialty
business.industry
Phases of clinical research
Hematology
Neutropenia
medicine.disease
03 medical and health sciences
Regimen
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
medicine
business
Pegfilgrastim
Multiple myeloma
Dexamethasone
030215 immunology
medicine.drug
Lenalidomide
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi...........133ed98e07cb2d4f717d092b6ba5bfa4