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Estimation of Monoamines concentration in rat brain after administration of Olanzepine Microsphere
- Source :
- Research Journal of Pharmacy and Technology. :1919-1922
- Publication Year :
- 2021
- Publisher :
- A and V Publications, 2021.
-
Abstract
- Olanzepine a potential antidepressant drug with high affinity of serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA) and noradrenaline (NA) in selected regions of the rat brain. Depression is a debilitating psychiatric condition that remains the second most common cause of disability worldwide. Hence the purpose of present study is to investigate effect of Olanzepine microsphere prepared by using combination of sodium alginate and carbopol polymer on monoamine concentration in rat brain. Our main aim is to study relationship such as serotonin (5HT), dopamine (DA) and nonadrenaline (NA)in the brain of rat It showed that significant reduction occur in monoamine formation in brain of rat. Thus study suggest that prepared Olanzepine microsphere showed decreased the monoamine on rat brain.
- Subjects :
- Chemistry
Pharmacology
Rat brain
030226 pharmacology & pharmacy
01 natural sciences
0104 chemical sciences
Microsphere
010404 medicinal & biomolecular chemistry
03 medical and health sciences
0302 clinical medicine
Monoamine neurotransmitter
Antidepressant
Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Subjects
Details
- ISSN :
- 0974360X and 09743618
- Database :
- OpenAIRE
- Journal :
- Research Journal of Pharmacy and Technology
- Accession number :
- edsair.doi...........139113bc5b5e824dfd60e7217e547845