Overexpression of PPARγ1 or 2 in Pancreatic β-cells Exacerbates Glucose Intolerance in Diet-induced Obese Mice

s / Can J Diabetes 36 (2012) S24eS76 S62 glucolipotoxicity and chronic ER stress. Interestingly, double BaxBak knockout resulted in an acute and transient up-regulation of the islet ER stress response. Together, these data suggest that Bax and Bak, both separately and in combination, are important for beta-cell loss in diabetes and have novel roles in the regulation of beta-cell organelle stress upstream of apoptosis execution.