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Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates
- Source :
- Metabolic Brain Disease. 36:169-183
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Physiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, schizophrenia symptom dimensions, and the Brief Assessment of Cognition in Schizophrenia. We measured neuro-immune markers including plasma CCL11 (eotaxin), interleukin-(IL)-6, IL-10, Dickkopf protein 1 (DKK1), high mobility group box 1 protein (HMGB1) and endogenous opioid system (EOS) markers including κ-opioid receptor (KOR), μ-opioid receptor (MOR), endomorphin-2 (EM2) and β-endorphin. Patients with an increased FF score display increased ratings of psychosis, hostility, excitement, formal though disorders, psycho-motor retardation and negative symptoms as compared with patients with lower FF scores. A large part of the variance in the FF score (55.1%) is explained by the regression on digit sequencing task, token motor task, list learning, IL-10, age (all inversely) and IL-6 (positively). Neural network analysis shows that the top-6 predictors of the FF score are (in descending order): IL-6, HMGB1, education, MOR, KOR and IL-10. We found that 45.1% of the variance in a latent vector extracted from cognitive test scores, schizophrenia symptoms and the FF score was explained by HMGB1, MOR, EM2, DKK1, and CCL11. Physiosomatic symptoms are an integral part of the phenome of schizophrenia. Neurotoxic immune pathways and lowered immune regulation coupled with alterations in the EOS appear to drive the physiosomatic symptoms of schizophrenia.
- Subjects :
- 0301 basic medicine
Oncology
Psychosis
medicine.medical_specialty
business.industry
Cognition
medicine.disease
behavioral disciplines and activities
Biochemistry
Cognitive test
03 medical and health sciences
Cellular and Molecular Neuroscience
030104 developmental biology
0302 clinical medicine
Fibromyalgia
Internal medicine
mental disorders
medicine
Chronic fatigue syndrome
Neurology (clinical)
business
Neurocognitive
030217 neurology & neurosurgery
CCL11
Endogenous opioid
Subjects
Details
- ISSN :
- 15737365 and 08857490
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Metabolic Brain Disease
- Accession number :
- edsair.doi...........176ca5da201e2fbeb1d0ba766bad1fec