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The crystal structures, spectrometric, photodynamic properties and bioimaging of β-β linked Bodipy oligomers
- Source :
- Journal of Luminescence. 212:306-314
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A series of β-β directly linked Bodipy oligomers (D1, D2, D3 and T1) based on different monomers are synthesized and the crystal structures, photophysical properties, singlet oxygen (1O2) generation abilities, bioimaging and phototoxicity are investigated. Single-crystal X-ray analyses of D1 and D2 indicate the distorted orthogonal conformation of two linked Bodipy planes. In comparison with the meso-β analogues, the β-β dimers exhibit red-shifted spectroscopy bands, strong fluorescent emission but modest 1O2 quantum yields due to the distorted orthogonal structures and electron interaction, which is demonstrated by single-crystal analysis, spectroscopy measurements and quantum calculations. The fluorescence imaging and cytotoxicity assay results indicate that the unsubstituted D1 and D2 with excellent bioimaging performance alongside with obvious phototoxicity are promising candidates in the fields of cell imaging and photodynamic therapy.
- Subjects :
- Fluorescence-lifetime imaging microscopy
Singlet oxygen
medicine.medical_treatment
Biophysics
Photodynamic therapy
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Photochemistry
01 natural sciences
Biochemistry
Fluorescence
Atomic and Molecular Physics, and Optics
0104 chemical sciences
chemistry.chemical_compound
Monomer
chemistry
medicine
BODIPY
0210 nano-technology
Spectroscopy
Phototoxicity
Subjects
Details
- ISSN :
- 00222313
- Volume :
- 212
- Database :
- OpenAIRE
- Journal :
- Journal of Luminescence
- Accession number :
- edsair.doi...........18376fe7886cb216f97cda313e27dc15