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An Autoimmune Encephalitis Case Associated with Pembrolizumab Use
- Source :
- Journal of the Korean Neurological Association. 40:137-140
- Publication Year :
- 2022
- Publisher :
- Korean Neurological Association, 2022.
-
Abstract
- Immune checkpoint inhibitors may be associated with various adverse events, including encephalitis. Here, we report a case of encephalopathy associated with pembrolizumab therapy. A 60-year-old male diagnosed with cholangiocarcinoma with peritoneal seeding presented altered mentality and cognitive function after using pembrolizumab. Electroencephalogram showed mild diffuse cerebral dysfunction. Cerebrospinal fluid (CSF) study showed no evidence of infection or autoimmune disease and no paraneoplastic antibody was detected from CSF and serum. After high-dose methylprednisolone intravenous infusion, patient’s mentality was fully recovered.
Details
- ISSN :
- 2288985X and 12257044
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of the Korean Neurological Association
- Accession number :
- edsair.doi...........18ae90d6825d8544c41fae34571c3b26