Dual metalloprotease inhibitors. IV. Utilization of thiazepines and thiazines as constrained peptidomimetic surrogates in mercaptoacyl dipeptides

Authors :: Chongqing Sun
Joyce A. Reid
J.Eileen Bird
Baerbel R. Brown
Denis E. Ryono
M. M. Asaad
Donald S. Karanewsky
Raj N. Misra
Jeffrey A. Robl
Nick C. Trippodo
Jagabandhu Das
Edward W. Petrillo
Source :: Bioorganic & Medicinal Chemistry Letters. 4:2193-2198
Publication Year :: 1994
Publisher :: Elsevier BV, 1994.
Abstract: A structure-activity study of the dual acting ACE/NEP inhibitors related to 1a and 1b was undertaken to determine the parameters critical for activity versus ACE and NEP in vitro.

Subjects :: Metalloproteinase
Peptidomimetic
Chemistry
Stereochemistry
fungi
Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Molecular Biology
Biochemistry
Combinatorial chemistry

Full Text Access

Tools