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Analysis of Clinico-Pathological Characteristics of Indian Breast Cancers Shows Conservation of Specific Features in the Hormone Receptor Sub-Types
- Source :
- Journal of Integrative Oncology.
- Publication Year :
- 2016
- Publisher :
- OMICS Publishing Group, 2016.
-
Abstract
- Background: Clinical epidemiology studies of breast cancer in India have reported younger age at detection, presentation at a later stage with a greater proportion of Triple Negative Breast Cancer (TNBC). The aim of this study was to examine the standard clinic-pathological variables in the hormone-receptor based sub-types for patterns indicative of intrinsic differences from that reported in Western, Caucasian women. Methods: Clinico-pathological variables from 645 patients who were diagnosed with breast cancer during 2012 at the regional cancer were retrospectively analyzed for clinical and immunohistochemistry details. Results: The median age at first diagnosis is 48 years which is decade earlier than that reported in Western case-series, 65% were lymph-node positive, and 33% of all cases were Triple negative Breast Cancers. Sub-type specific examination of tumor size and lymph-node (LN) status showed the HER2 positive tumors to have the highest proportion of tumors that were pT4 and 75% were LN positive. Conversely, despite 92% of TNBCs being grade 3, 40% of them were LN negative. Conclusion: We confirm the three cardinal clinical epidemiological features reported by other Indian centres. The clinical behavior of the HER2 positive and TNBC sub-types are no different from that reported in Western caseseries suggesting that these aspects are innate and conserved.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Pathology
business.industry
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Breast cancer
Hormone receptor
030220 oncology & carcinogenesis
Internal medicine
Epidemiology
medicine
Sub types
Immunohistochemistry
Clinico pathological
Stage (cooking)
business
Triple-negative breast cancer
Subjects
Details
- ISSN :
- 23296771
- Database :
- OpenAIRE
- Journal :
- Journal of Integrative Oncology
- Accession number :
- edsair.doi...........1a65117325cb9b3c52d794971245f3b3