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Medicinal Uses of Marijuana and Cannabinoids
- Source :
- Critical Reviews in Plant Sciences. 35:378-405
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- In the past two decades, there has been increasing interest in the therapeutic potential of cannabis and single cannabinoids, mainly cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). THC and cannabis products rich in THC exert their effects mainly through the activation of cannabinoid receptors (CB1 and CB2). Since 1975, 140 controlled clinical trials using different cannabinoids or whole-plant preparations for the treatment of a large number of disorders and symptoms have been conducted. Results have led to the approval of cannabis-based medicines [dronabinol, nabilone, and the cannabis extract nabiximols (Sativex®, THC:CBD = 1:1)] as well as cannabis flowers in several countries. Controlled clinical studies provide substantial evidence for the use of cannabinoid receptor agonists in cancer chemotherapy induced nausea and vomiting, appetite loss and cachexia in cancer and HIV patients, neuropathic and chronic pain, and in spasticity in multiple sclerosis. In addition, there is also some e...
- Subjects :
- Cannabinoid receptor
biology
business.industry
organic chemicals
Nabiximols
Cannabinoid Receptor Agonists
Plant Science
Pharmacology
biology.organism_classification
Endocannabinoid system
Nabilone
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
mental disorders
Medicine
lipids (amino acids, peptides, and proteins)
Dronabinol
Cannabis
business
Cannabidiol
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 15497836 and 07352689
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Plant Sciences
- Accession number :
- edsair.doi...........1a870af1574594421c7f6e6b0b33279b
- Full Text :
- https://doi.org/10.1080/07352689.2016.1265360