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Medicinal Uses of Marijuana and Cannabinoids

Authors :
Kirsten R. Müller-Vahl
Franjo Grotenhermen
Source :
Critical Reviews in Plant Sciences. 35:378-405
Publication Year :
2016
Publisher :
Informa UK Limited, 2016.

Abstract

In the past two decades, there has been increasing interest in the therapeutic potential of cannabis and single cannabinoids, mainly cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). THC and cannabis products rich in THC exert their effects mainly through the activation of cannabinoid receptors (CB1 and CB2). Since 1975, 140 controlled clinical trials using different cannabinoids or whole-plant preparations for the treatment of a large number of disorders and symptoms have been conducted. Results have led to the approval of cannabis-based medicines [dronabinol, nabilone, and the cannabis extract nabiximols (Sativex®, THC:CBD = 1:1)] as well as cannabis flowers in several countries. Controlled clinical studies provide substantial evidence for the use of cannabinoid receptor agonists in cancer chemotherapy induced nausea and vomiting, appetite loss and cachexia in cancer and HIV patients, neuropathic and chronic pain, and in spasticity in multiple sclerosis. In addition, there is also some e...

Details

ISSN :
15497836 and 07352689
Volume :
35
Database :
OpenAIRE
Journal :
Critical Reviews in Plant Sciences
Accession number :
edsair.doi...........1a870af1574594421c7f6e6b0b33279b
Full Text :
https://doi.org/10.1080/07352689.2016.1265360