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Long stability of SARS-CoV-2 RNA in dry and saliva swab samples stored for diagnostics, Denmark

Authors :
Arieh Cohen
Jørgensen Mgp
Sofie Holdflod Nielsen
Worsøe Rosenstierne M
Crone S
Anna S. Fomsgaard
Ellinor Marving
Alonzo Alfaro-Núñez
Shila Mortensen
Claus Nielsen
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

During the current COVID-19 pandemic, Danish authorities demand that clinical swab samples must be analysed within 72 hours. This time constraint was adopted to guarantee a quick and efficient response. As today, analysis results are given within 20 hours average fulfilling this demand. However, it is unclear for how long and under which conditions swab specimens can be stored without clinically affecting SARS-CoV-2 RNA stability. This study demonstrates that swabs specimens can be stored at −20°C and +4°C for up to 26 days without affecting RT-qPCR results. However, early detection of asymptomatic cases is important to reduce spreading COVID-19 may be the final consequence not only in Denmark but worldwide.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........1b1ffd71966179aff6aaa7e2fed5b322