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Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats
Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats
- Source :
- Brain Research. 1712:132-138
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The present study aimed to investigate cerebral metabolic changes in a neuropathic pain model following deafferentation. A total of 24 Sprague-Dawley rats were included for modeling of right brachial plexus avulsion (BPA) through the posterior approach. As nerve injury would cause central sensitization and facilitate pain sensitivity in other parts of the body, thermal withdrawal latency (TWL) of the intact forepaw was assessed to investigate the level of pain perception following BPA-induced neuropathic pain. [Fluorine-18]-fluoro-2-deoxy- d -glucose (18F-FDG) positron emission tomography (PET) was applied to the brain before and after brachial plexus avulsion to explore metabolic changes in neuropathic pain following deafferentation. The TWL of the left (intact) forepaw was significantly lower after BPA than that of baseline (p
- Subjects :
- 0301 basic medicine
PET-CT
medicine.diagnostic_test
business.industry
General Neuroscience
Withdrawal latency
Nerve injury
Posterior approach
Brachial plexus avulsion
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Positron emission tomography
Anesthesia
Neuropathic pain
medicine
Pain perception
Neurology (clinical)
medicine.symptom
business
Molecular Biology
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1712
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi...........1ba5c73a32010820761a96c1d9378581
- Full Text :
- https://doi.org/10.1016/j.brainres.2019.02.005