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Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats

Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats

Authors :
Bei-Bei Huo
Chun-Lei Shan
Mou-Xiong Zheng
Jian-Guang Xu
Jun Shen
Ye-Chen Lu
Xu-Yun Hua
Jia-Jia Wu
Source :
Brain Research. 1712:132-138
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

The present study aimed to investigate cerebral metabolic changes in a neuropathic pain model following deafferentation. A total of 24 Sprague-Dawley rats were included for modeling of right brachial plexus avulsion (BPA) through the posterior approach. As nerve injury would cause central sensitization and facilitate pain sensitivity in other parts of the body, thermal withdrawal latency (TWL) of the intact forepaw was assessed to investigate the level of pain perception following BPA-induced neuropathic pain. [Fluorine-18]-fluoro-2-deoxy- d -glucose (18F-FDG) positron emission tomography (PET) was applied to the brain before and after brachial plexus avulsion to explore metabolic changes in neuropathic pain following deafferentation. The TWL of the left (intact) forepaw was significantly lower after BPA than that of baseline (p

Details

ISSN :
00068993
Volume :
1712
Database :
OpenAIRE
Journal :
Brain Research
Accession number :
edsair.doi...........1ba5c73a32010820761a96c1d9378581
Full Text :
https://doi.org/10.1016/j.brainres.2019.02.005