New Multifunctional Complexes [Ru(κ 3 ‐L)(EPh 3 ) 2 Cl] + [E = P, As; L = 2,4,6‐Tris(2‐pyridyl)‐1,3,5‐triazine] Containing both Group <scp>V</scp> and Polypyridyl Ligands

Synthesis, structure, reactivity and enzyme inhibitory activity of the new cationic ruthenium complexes [Ru(κ3-L)(EPh3)2Cl]BF4 [L = 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz); E = P (1), As (2)] and their substitution products [Ru(κ3-tptz)(PPh3)(dtc)]Cl (3), [Ru(κ3-tptz)(PPh3)(CN)2] (4), [Ru(κ3-tptz)(AsPh3)(dtc)]BF4 (5), and [Ru(κ3-tptz)(AsPh3)(CN)2] (6) are reported. The complexes were characterized by analytical and spectroscopic methods and the structures of the complexes 1, 2 and 3 determined by X-ray diffraction studies. C−H···X (X = Cl, F and S), C−H···π and π−π interactions were observed in these complexes. Further studies indicated that the complexes [Ru(κ3-L)(EPh3)2Cl]+ could find application as precursors in the synthesis of other ruthenium complexes or as metallo-ligands. The complexes also interact with DNA, which was illustrated by absorption titration studies with CT-DNA and inhibition of topoisomerase II of the filarial parasite Setaria cervi. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)