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Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests
- Source :
- Clinical Chemistry. 46:2027-2049
- Publication Year :
- 2000
- Publisher :
- Oxford University Press (OUP), 2000.
-
Abstract
- Purpose: To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury.Data Sources and Study Selection: A MEDLINE search was performed for key words related to hepatic tests, including quality specifications, aminotransferases, alkaline phosphatase, γ-glutamyltransferase, bilirubin, albumin, ammonia, and viral markers. Abstracts were reviewed, and articles discussing performance of laboratory tests were selected for review. Additional articles were selected from the references.Guideline Preparation and Review: Drafts of the guidelines were posted on the Internet, presented at the AACC Annual Meeting in 1999, and reviewed by experts. Areas requiring further amplification or literature review were identified for further analysis. Specific recommendations were made based on analysis of published data and evaluated for strength of evidence and clinical impact. The drafts were also reviewed by the Practice Guidelines Committee of the American Association for the Study of Liver Diseases and approved by the committee and the Association’s Council.Recommendations: Although many specific recommendations are made in the guidelines, some summary recommendations are discussed here. Alanine aminotransferase is the most important test for recognition of acute and chronic hepatic injury. Performance goals should aim for total error of
- Subjects :
- Prothrombin time
Hepatitis
medicine.medical_specialty
medicine.diagnostic_test
biology
business.industry
Biochemistry (medical)
Clinical Biochemistry
MEDLINE
Guideline
medicine.disease
Surgery
Liver disease
Alanine transaminase
biology.protein
Medicine
business
Intensive care medicine
Viral hepatitis
Liver function tests
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi...........1ccea46cba4d8deea3a70cdc72484999