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HIGHLY EFFICIENT SYNTHESIS OF 2-AMINO-3-PYRIDINECARBOXALDEHYDE
- Source :
- Synthetic Communications. 31:1573-1579
- Publication Year :
- 2001
- Publisher :
- Informa UK Limited, 2001.
-
Abstract
- 2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloylamino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.
Details
- ISSN :
- 15322432 and 00397911
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Synthetic Communications
- Accession number :
- edsair.doi...........1dd8c006cc213045f8e92f22ba22c0b0