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Is there a prognostic role for C-reactive protein in ischemic stroke?

Authors :
Edo Bottacchi
M E Di Benedetto
Guido Giardini
Giovanni Corso
M. Veronese Morosini
M. Reggiani
Chiara Lia
Adriana Brusa
Source :
Acta Neurologica Scandinavica. 122:209-216
Publication Year :
2009
Publisher :
Hindawi Limited, 2009.

Abstract

Corso G, Bottacchi E, Brusa A, Di Benedetto M, Giardini G, Lia C, Reggiani M, Veronese Morosini M. Is there a prognostic role for C-reactive protein in ischemic stroke? Acta Neurol Scand: 122: 209–216. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – We investigated the relationship between C-reactive protein (CRP)-values in the acute phase of stroke and the risk of further fatal and non-fatal ischemic events. Materials and methods – We analysed 462 consecutive incident ischemic strokes. Patients were divided into two subgroups on the basis of a CRP cut-off level of 9 mg/l. Primary end points were any new vascular fatal and non-fatal event recorded during the follow-up period. Results – During a follow-up of 2.27 years, in 132 patients occurred a primary end point. Patients with CRP values ≥9 mg/l had more frequently primary end point. The hazard ratio (HR) for cardiovascular events was 3.59; 1.93 for cerebrovascular events; 7.43 for vascular deaths and 5.78 for death from any cause. Cox proportional hazard multivariate analysis identified CRP values ≥9 (HR = 4.19, 95% CI: 1.85–9.50, P = 0.001), the lack of secondary prevention therapy at discharge (HR = 4.35, 95% CI: 1.87–10.1, P = 0.001), age >70 years (HR = 3.09, 95% CI: 1.04–9.24, P = 0.04) as independent predictors of fatal events. Conclusions – CRP levels ≥9 mg/l, evaluated in incident ischemic stroke within 24 h, predict a higher risk of further ischemic events and mortality.

Details

ISSN :
00016314
Volume :
122
Database :
OpenAIRE
Journal :
Acta Neurologica Scandinavica
Accession number :
edsair.doi...........1ed069b7504e8a9d32ba49ebc9742269
Full Text :
https://doi.org/10.1111/j.1600-0404.2009.01288.x