Back to Search
Start Over
Human Recombinant Follistatin-288 Suppresses Plasma Concentrations of Follicle-Stimulating Hormone but is not a Significant Regulator of Luteinizing Hormone in Castrated Rams1
- Source :
- Biology of Reproduction. 53:1353-1358
- Publication Year :
- 1995
- Publisher :
- Oxford University Press (OUP), 1995.
-
Abstract
- We have tested the hypothesis that treatment of castrated rams (wethers) with human recombinant follistatin-288 (FS-288) suppresses plasma concentrations of FSH but has no effect on plasma concentrations of LH. Wethers were given an i.v. injection of vehicle or 50 micrograms FS-288 followed by a 12-h i.v. infusion of vehicle or 800 micrograms FS-288, respectively. This dose and treatment regimen was identical to that used in a previous study in which wethers were treated with vehicle or human recombinant inhibin A (hr-inhibin). Human recombinant follistatin significantly (p < 0.05) suppressed plasma concentrations of FSH, but vehicle had no effect. The maximal suppression of FSH occurred 12-15 h after the start of treatment, at which time the plasma concentrations were reduced by 20.6%. The reduction in plasma concentrations of FSH caused by FS-288 was about 2.6-fold less than that observed after the same treatment with hr-inhibin. FS-288 had no effect on plasma concentrations of LH; this result was similar to the findings we obtained with hr-inhibin. These data suggest that follistatin is a less potent negative regulator of FSH secretion than inhibin and that follistatin is not a significant regulator of the secretion of LH in rams.
- Subjects :
- endocrine system
medicine.medical_specialty
medicine.drug_class
Biological activity
Cell Biology
General Medicine
Biology
law.invention
Follicle-stimulating hormone
Endocrinology
Reproductive Medicine
law
Internal medicine
medicine
Recombinant DNA
biology.protein
Secretion
Orchiectomy
Gonadotropin
Luteinizing hormone
hormones, hormone substitutes, and hormone antagonists
Follistatin
Subjects
Details
- ISSN :
- 15297268 and 00063363
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Biology of Reproduction
- Accession number :
- edsair.doi...........1f56d66546a14d7ec0d1ec150b778a47