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Immunoscreening of Alpha-Tocopherol in Breast, Prostate Cancers and in Gestational Choriocarcinoma Tissues

Authors :
Alexis Fortuné Bolenga Liboko
Michel Geffard
Henriette Poaty
Judith Nsonde Malanda
Franck Arnaud Moukobolo Kinsangou
Source :
CellBio. 10:11-21
Publication Year :
2021
Publisher :
Scientific Research Publishing, Inc., 2021.

Abstract

Background: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (α-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. Methods: α-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. Results: α-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. Conclusion: Tumors immunohistochemistry of α-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.

Details

ISSN :
23257792 and 23257776
Volume :
10
Database :
OpenAIRE
Journal :
CellBio
Accession number :
edsair.doi...........1f60c48c82179faf73d38e4dc5c0001a
Full Text :
https://doi.org/10.4236/cellbio.2021.102002