Poor Outcome of Pediatric Patients with Acute Myeloid Leukemia Harbour High FLT3/ITD Allelic Ratios

Purpose: To evaluate the outcome and prognostic significance of FLT3/ITD allelic ratios (AR) among pediatric acute myeloid leukemia (AML) from TARGET dataset. Methods: A total of 1,857 pediatric patients who were diagnosed with AML were enrolled in this study by using a retrospective cohort study method from September 1996 to December 2016. Results: The prevalence of FLT3/ITD mutation in the whole cohort was 18.4%. Generalized additive models and threshold effect analysis using piece-wise linear regression were applied to identify the cut-off value of 0.5 on FLT3/ITD AR. High FLT3/ITD AR were significantly associated with higher WBC ( P