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Synthesis of Acyl Thiourea Derivatives of 7-Trifluoromethyl-2-Pyridylquinazolin-4(3H)-one as Anticancer Agents
- Source :
- Journal of Chemical Research. 41:598-602
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- A new series of 7-trifluoromethyl-2-pyridylquinazolin-4(3 H)-one-based acyl thiourea derivatives has been generated and tested for their cytotoxicity towards human ovarian cancer (SK-OV-3), cervical cancer (HeLa), renal cancer (Caki-2) cell lines, as well as noncancerous a human umbilical vein endothelial cell (HUVEC) line. The new thiourea derivatives were found to be promisingly cytotoxic towards the cancerous cell lines. Changing the substituent at the thiourea linkage led to variations in the cytotoxic potential of the resultant derivatives towards specific cell lines. Molecules with fluorine functionality and multiple pyridyl moieties showed encouraging anticancer effects and could be used as a platform for the design of further chemotherapeutic agents. The proposed structures of the products were ascertained through FTIR, mass, 1H NMR and 13C NMR spectra and elemental analyses.
- Subjects :
- Trifluoromethyl
010405 organic chemistry
General Chemistry
medicine.disease
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Thiourea
030220 oncology & carcinogenesis
medicine
MTT assay
Cytotoxicity
Ovarian cancer
Subjects
Details
- ISSN :
- 20476507 and 17475198
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Chemical Research
- Accession number :
- edsair.doi...........1f8085eab206a4d1e2c2460bfc4e2cc3