Back to Search Start Over

Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer

Authors :
Tristan D. Yan
Weiqiang Yin
Yingying Gu
Mingcong Mo
Christopher Cao
Guoqin Chen
Jun Liu
Wei Wang
Wenlong Shao
Hanzhang Chen
Xin Guo Xiong
Jianxing He
Source :
Journal of Surgical Oncology. 104:841-846
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

Background The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). Methods One hundred and forty-six consecutive and non-selected patients who underwent definitive surgery for stage IA NSCLC were included in this study. Formalin-fixed paraffin-embedded specimens were stained for MMP-2 and MMP-9, which were statistically evaluated for their prognostic value and other clinicopathological parameters. Results Of the 146 patients studied, 102 (69.9%) cases were classified as having high expression for MMP-2. A total of 89 carcinomas (61.0%) had high expression for MMP-9. MMP-9 expression correlated with Eastern Cooperative Oncology Group (ECOG) performance status, pT stage, and differentiation (P = 0.005

Details

ISSN :
00224790
Volume :
104
Database :
OpenAIRE
Journal :
Journal of Surgical Oncology
Accession number :
edsair.doi...........1fdfa0988ef142957b7f2f4152c24fd9
Full Text :
https://doi.org/10.1002/jso.22001