Back to Search
Start Over
Structure—activity relationships for in vitro oxime reactivation of chlorpyrifos-inhibited acetylcholinesterase
- Source :
- Chemical Papers. 61
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Organophosphorus pesticides parathion, chlorpyrifos, and malathion inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication by these AChE inhibitors. In this work, chlorpyrifos, a representative member of this pesticide family, was used to inhibit the AChE activity of rat brain. The effect of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined.
- Subjects :
- chemistry.chemical_classification
Aché
Stereochemistry
General Chemical Engineering
Biological activity
General Chemistry
Biochemistry
Acetylcholinesterase
Industrial and Manufacturing Engineering
language.human_language
chemistry.chemical_compound
Parathion
Enzyme
chemistry
Chlorpyrifos
Materials Chemistry
language
Structure–activity relationship
Malathion
Subjects
Details
- ISSN :
- 13369075
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Chemical Papers
- Accession number :
- edsair.doi...........1ff3f4ea0d8d79cfaa370e35b601e9fa