Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial

Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.